The internal cleanliness, chemical stability, air tightness and biological properties of butyl rubber stoppers are very good, but due to the complex formula and the concentration gradient of the added raw materials, after being encapsulated with some drugs with relatively strong molecular activity, they are blocked by the drug. Absorption, adsorption, leaching, and permeation lead to compatibility problems between rubber stoppers and drugs. Therefore, by choosing an inert soft coating to cover the surface of the rubber stopper to isolate the direct contact between the medicine and the rubber stopper, the compatibility with the medicine can be significantly improved.
After the butyl rubber stopper is covered with a film, because of its many potentials, such as by forming a film on the surface of the rubber stopper, it can be reflected in the following aspects:
1. Improve the long-term stability of the drug by forming a film on the surface of the rubber stopper;
2. It can effectively reduce the absorption, adsorption, leaching and penetration between the rubber stopper and the drug, and improve the long-term stability of the drug;
3. Improve the mechanical lubricity of the rubber stopper;
4. Greatly reduce the increase in the number of insoluble particles in the liquid due to silicone oil;
5. Cleanliness, chemical stability, air tightness and biological properties are all very good;
6. Low gas permeability;
7. High chemical resistance;
8. It has high internal cleanliness.
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