Natural rubber has some biological proteins remaining in the glue. Protein is not only an active allergic substance, but also prone to mold growth, which is harmful to living organisms. Butyl rubber has good biological reliability, and the medicine encapsulated by the stopper must enter the human body. Therefore, the medicinal stopper should have no pyrogen, no abnormal toxicity, no hemolytic reaction, etc., so as to ensure the reliability of medication.
Butyl rubber stopper has good air tightness, good heat resistance, good acid and alkali resistance, and high internal cleanliness, and soon replaced natural rubber in the production of medicinal bottle stoppers. Butyl rubber is a synthetic rubber made of isobutylene and a small amount of isoprene (<3%) polymerized at ultra-low temperature (95°C). The reliability of medication is also reduced, and the process of waxing and waxing and the process of adding polyester film to the production of natural rubber stoppers are also reduced. Butyl rubber stoppers are much larger than natural rubber stoppers in terms of product standards, production levels, performance, and product quality.
The internal cleanliness, chemical stability, air tightness and biological properties of butyl rubber stoppers are very good, but due to the complex formula and the concentration gradient of the added raw materials, after encapsulation with some drugs with strong molecular activity, they are absorbed by the drugs. , adsorption, leaching, penetration, resulting in the compatibility of rubber stoppers and drugs. Therefore, by choosing an inert soft coating to cover the surface of the rubber stopper to isolate the direct contact between the medicine and the rubber stopper, the compatibility with the medicine can be significantly improved. By forming a film on the surface of the butyl rubber plug, the absorption, adsorption, leaching and penetration between the rubber plug and the drug can be effectively reduced, the long-term stability of the drug can be improved, and the mechanical lubricity of the rubber plug can be improved.
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